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Difference in serum proteome between HCC and non-HCC groups. (A) Volcano plot of serum <t>proteomic</t> profiles in HCC vs non-HCC. (B) Heatmap of serum proteomic profiles in the two groups. (C) BP pathway analyses with DEPs. (D) CC pathway analyses with DEPs. (E) MF pathway analyses with DEPs. (F) KEGG pathway analyses with DEPs. (G) PPI network analysis of the interactions between the two groups. (H) GSEA pathway analyses in two groups.
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Difference in serum proteome between HCC and non-HCC groups. (A) Volcano plot of serum <t>proteomic</t> profiles in HCC vs non-HCC. (B) Heatmap of serum proteomic profiles in the two groups. (C) BP pathway analyses with DEPs. (D) CC pathway analyses with DEPs. (E) MF pathway analyses with DEPs. (F) KEGG pathway analyses with DEPs. (G) PPI network analysis of the interactions between the two groups. (H) GSEA pathway analyses in two groups.
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Difference in serum proteome between HCC and non-HCC groups. (A) Volcano plot of serum proteomic profiles in HCC vs non-HCC. (B) Heatmap of serum proteomic profiles in the two groups. (C) BP pathway analyses with DEPs. (D) CC pathway analyses with DEPs. (E) MF pathway analyses with DEPs. (F) KEGG pathway analyses with DEPs. (G) PPI network analysis of the interactions between the two groups. (H) GSEA pathway analyses in two groups.

Journal: Frontiers in Oncology

Article Title: Serum proteomics and metabolomics reveal novel noninvasive molecular signatures for hepatocellular carcinoma diagnosis

doi: 10.3389/fonc.2026.1797408

Figure Lengend Snippet: Difference in serum proteome between HCC and non-HCC groups. (A) Volcano plot of serum proteomic profiles in HCC vs non-HCC. (B) Heatmap of serum proteomic profiles in the two groups. (C) BP pathway analyses with DEPs. (D) CC pathway analyses with DEPs. (E) MF pathway analyses with DEPs. (F) KEGG pathway analyses with DEPs. (G) PPI network analysis of the interactions between the two groups. (H) GSEA pathway analyses in two groups.

Article Snippet: The expression of GRHPR was further validated using Clinical Proteomic Tumor Analysis Consortium (CPTAC) proteomics data from the Human Protein Atlas (HPA).

Techniques:

GRHPR Downregulation and Independent Prognostic Value in HCC. (A) Validation of GRHPR protein expression using CPTAC proteomics data from the HPA. (B) Kaplan-Meier survival analysis of GRHPR. (C) Univariate Cox regression analysis of prognostic factors in HCC patients. (D) Multivariate Cox regression analysis of prognostic factors in HCC patients.

Journal: Frontiers in Oncology

Article Title: Serum proteomics and metabolomics reveal novel noninvasive molecular signatures for hepatocellular carcinoma diagnosis

doi: 10.3389/fonc.2026.1797408

Figure Lengend Snippet: GRHPR Downregulation and Independent Prognostic Value in HCC. (A) Validation of GRHPR protein expression using CPTAC proteomics data from the HPA. (B) Kaplan-Meier survival analysis of GRHPR. (C) Univariate Cox regression analysis of prognostic factors in HCC patients. (D) Multivariate Cox regression analysis of prognostic factors in HCC patients.

Article Snippet: The expression of GRHPR was further validated using Clinical Proteomic Tumor Analysis Consortium (CPTAC) proteomics data from the Human Protein Atlas (HPA).

Techniques: Biomarker Discovery, Expressing